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Museum of Pathology

ASTROCYTOMA GRADE II

ASTROCYTOMA GRADE II

Clinical History

Patient aged 70 years who was a known diabetic with a 3/52 history of increasing confusion, vulgarity and urinary incontinence. Brain scan showed a large mid-line lesion, extending laterally into the posterior part of both frontal regions. At craniotomy the tumour was biopsied. Post-operatively the patient became febrile with rising blood urea. He developed melaena and died the following day.

Pathology

This coronal section of the brain demonstrates a pale cream, friable growth which occupies the corpus callosum and is infiltrating the cerebral hemispheres on either side of the mid-line. Note that there is no clear demarcation between the tumour and normal white matter but the tumour can be recognised as being paler and of a spongy appearance. Microscopically this was an astrocytoma Grade II.