A woman of 53 gave a history of transient left-sided weakness over the previous 12 months, headache for 6 weeks and recent confusion. Clinical examination revealed papilloedema and a left hemiplegia. A right carotid arteriogram showed a tumour in the posterior portion of the corpus callosum and an EEG suggested a lesion in the right temporo-parietal region. The patient was treated with radiotherapy but her condition suddenly deteriorated.
The slice of brain displays the posterior cut surface and shows a haemorrhagic tumour extending across the midline beneath the splenium of the corpus callosum to involve both cerebral hemispheres. The right hemisphere is swollen and haemorrhages are present in the brain stem. Lateral ventricles are compressed. Histologically the tumour was a grade III astrocytoma.