[ Monash University ]

Museum of Pathology

LYMPHOMA IN SPLEEN

LYMPHOMA IN SPLEEN

Clinical History

This patient was a 48 year old male, admitted with a story of vague ill-health commencing 2 years previously. Lassitude became worse and was associated with cough. Six months prior to admission cervical gland enlargement was noticed. Three months after this, spleen and axillary nodes were enlarged. Three weeks prior to admission there was marked pallor, dyspnoea and angina at rest, and two weeks after this the patient became icteric. He was admitted and submitted to splenectomy as hypersplenism was thought to be a factor in the aetiology of his anaemia. He developed congestive cardiac failure post-operatively and died suddenly.

Pathology

The specimen is a spleen sliced along its long axis. The spleen is greatly enlarged and is a dark brown colour. Projecting from the cut surface are small roughly circular areas, 1-2 mm in diameter and having a slightly translucent appearance. Some of the veins which have been cut across, contain antemortem thrombus. Histologically the spleen showed lymphocytic lymphoma and was markedly congested. At necropsy there was widespread lymphadenopathy and extension of plum-coloured marrow down the femoral shafts. There was also a recent myocardial infarction.